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KMID : 1188320140080040408
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Gut and Liver
2014 Volume.8 No. 4 p.408 ~ p.414
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Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to Helicobacter pylori Infection Status: A Single-Center Experience
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Ryu Kwang-Duck
Kim Gwang-Ha
Park Seong-Oh
Lee Kwang-Jae
Moon Jung-Youn
Jeon Hye-Kyung
Baek Dong-Hoon
Lee Bong-Eun
Song Geun-Am
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Abstract
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Background/Aims:Helicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treatment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas.
Methods:In total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treatment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas.
Results:Of the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treatment, and complete remission was achieved in 31 of the 39 patients (80%) with H. pylori-positive MALT lymphoma and in five (56%) of the nine patients with H. pylori-negative MALT lymphoma; no significant difference was observed between the groups (p=0.135). The other treatment modalities, including radiation therapy, chemotherapy, and surgery, were effective irrespective of H. pylori infection status, with no significant difference in the treatment response between H. pylori-positive and H. pylori-negative MALT lymphomas.
Conclusions:H. pylori eradication therapy may be considered as a first-line treatment regardless of H. pylori infection status.
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KEYWORD
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Lymphoma, B-cell, marginal zone, Stomach, Helicobacter pylori, Eradication, Radiotherapy
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